liver injury — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T8733	Antrodin A	camphorataanhydride A	Others
	Antrodin A (camphorataanhydride A) (AdA) is one of the main active ingredients in the solid-state fermented A. camphorata mycelium. It protects the liver from alcohol damage by improving the antioxidant and anti-inflamma...		Others
T1677	Montelukast	Singular	Leukotriene Receptor , Lipoxygenase , LTR
	Montelukast (Singular) is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma and has been linked to rare cases of clinically apparent liver injury...		Leukotriene Receptor , Lipoxygenase , LTR
T1677L	Montelukast sodium	MK0476	Leukotriene Receptor , LTR
	Montelukast sodium (MK0476) is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma and has been linked to rare cases of clinically apparent liver i...		Leukotriene Receptor , LTR
T22323	Enoxaparin sodium		Thrombin
	Enoxaparin sodium is a low-molecular-weight heparin (LMWH) that has recently been approved by the US FDA for use in patients with medically managed ST-segment myocardial infarction (STEMI), or STEMI with subsequent percu...		Thrombin
T2171	SEW2871	SEW2871	S1P Receptor , LPL Receptor
	SEW 2871 is an orally available, highly selective S1P1 agonist with an EC50 of 13.8 nM.It reduces the number of lymphocytes in the blood and is used in studies related to diabetes, Alzheimer's disease, liver fibrosis, an...		S1P Receptor , LPL Receptor
T1090	Perphenazine	Perphenazin,Etaperazine,Trilafon	CaMK , Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , Histamine Receptor
	Perphenazine (Trilafon) is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties.
TQ0226	Jionoside B1		Others
	Jionoside B1 has immunosuppressive activity and shows the hepato-protective activity in the H2O2 induced liver injury experiments.		Others
T69360	RO3244794		Prostaglandin Receptor
	RO3244794 is a selective prostacyclin (IP) receptor antagonist that can be used to study liver injury.		Prostaglandin Receptor
T14491	B022		NF-κB
	B022 is a selective and potent NF-κB-induced kinase (NIK) inhibitor (Ki: 4.2 nM), a chemical probe for the treatment of liver inflammation and injury.B022 protects the liver from inflammation and injury caused by oxidati...		NF-κB
T28089	MPGES-1 Inhibitor-1		Prostaglandin Receptor
	mPGES-1 Inhibitor-1 is a novel selective inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1) with anti-inflammatory and analgesic activity for the study of acute liver injury.		Prostaglandin Receptor
T2555	Aclidinium bromide	LAS 34273,LAS-W 330	AChR
	Aclidinium bromide (LAS-W 330) is a synthetic anticholinergic agent that is used as an inhalant for treatment of acute bronchospasm due to chronic bronchitis or emphysema. Aclidinium has not been implicated in causing li...		AChR
T31795	FK-330	LS-192510,FR-260330,FK330,FK 330	NOS
	FK-330 (FR-260330) is a novel orally active inducible nitric oxide synthase inhibitor with potential anticancer and antitumor activity that prevents ischemia and reperfusion injury in rat liver transplantation.		NOS
T7045	Clonidine	Nexiclon,Catapres,Kapvay	Adrenergic Receptor
	Clonidine (Kapvay) is a centrally active alpha-adrenergic agonist used predominantly as an antihypertensive agent, usually in combination with other agents. Despite wide-scale use for many years, clonidine has not been l...		Adrenergic Receptor
TN4661	Nodosin		IL Receptor , Autophagy
	Nodosin has anti-inflammatory function of Nodosin via inhibition of IL-2. Nodosin perfusion provides a potential protective effect through inducing HO-1 expression to attenuate ischemia/reperfusion injury in liver transp...		IL Receptor , Autophagy
T1472	Trospium chloride	Spasmex,Sanctura	AChR
	Trospium chloride (Spasmex) is an antispasmodic and anticholinergic agent used to treat urinary incontinence and overactive bladder syndrome. Trospium chloride has not been implicated in causing liver enzyme elevations o...		AChR
T3273	Bifendate	Bifendatatum	HBV , Reverse Transcriptase
	Bifendate (Bifendatatum) is commonly used to treat the transaminase elevation that caused by viral hepatitis and drug-induced liver injury.		HBV , Reverse Transcriptase
T0226	Betaxolol hydrochloride	SL75212,SL 75212 HCl,Betaxolol HCl	Adrenergic Receptor
	Betaxolol hydrochloride (SL 75212 HCl) is a cardioselective beta-blocker used in the treatment of hypertension.Betaxolol hydrochloride has not been linked to instances of clinically apparent drug induced liver injury.		Adrenergic Receptor
T37859	SY-640		Endogenous Metabolite
	SY-640 is an Acetamide derivative. SY-640 exhibits potent hepatoprotective effect. SY-640 reduces liver injury in mice induced by Propionibacterium acnes and Lipopolysaccharide.		Endogenous Metabolite
T17018	TCPOBOP		BCL
	TCPOBOP is a constitutive androstane receptor agonist that induces robust hepatocyte proliferation and hepatomegaly. TCPOBOP decreases Fas-induced murine liver injury by altering Bcl-2 proteins.		BCL
T1655	Ambrisentan	BSF-208075,BSF 208075,LU 208075	Endothelin Receptor
	Ambrisentan (BSF 208075) is an endothelin receptor antagonist used in the therapy of pulmonary arterial hypertension (PAH). Ambrisentan has been associated with a low rate of serum enzyme elevations during therapy but ha...		Endothelin Receptor